Solution for injection: doxapram-based respiratory stimulant (analeptic).
Bottle per 10 ml.
Analeptic. Cardiac and pulmonary stimulant through carotid chemoreceptors. The respiratory center at CNS level is stimulated with higher doses.
In animals with ventilatory depression due to barbiturates, buprenorphine, xylazine and inhaled agents. It accelerates post-anesthesia recovery. It stimulates start of breathing in depressed newborns. To measure circulation time in horses.
100 mL of solution contains:
Doxapram hydrochloride 2 g.
Excipients q.s.
Equines: 0.5 mg/kg (equivalent to 2.5 mL every 100 kg of weight) IV. This dose can be repeated after 15-20 min.
Canine - Feline: Depression due to inhalation anesthesia: 1 mg/kg IV; due to barbiturates, xylazine and buprenorphine: 5 to 10 mg/kg IV.
Newborns: 1 to 2 drops of the solution by injection, sublingual, by umbilical vein or subcutaneous route.
CONTRAINDICACIONES
Do not administer to animals with seizure-causing illnesses, heart failure or pneumothorax. Do not administer to pregnant females.
Doxapram causes an uninterrupted increase in heart rate during the first minute after administration, as well as abnormalities in the magnitude and polarity of the T wave visible in the ECG. Both effects are transitory and are not enhanced by a second administration of the product.
Do not use in pregnant females.
Use with caution in patients with a history of respiratory diseases, arrhythmias or tachycardia. Do not administer more than 2 times with a 15-20 minute interval. It is essential for administration that the animal’s airways are not obstructed.
